WikiDoc Resources for List of IARC Group 4 carcinogens |
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Chemical carcinogens can be classified into one of four groups according to their chemical nature: organic carcinogens, inorganic carcinogens, fibers, and hormones. Laboratory procedures are now available that can be used as biologic markers of factors related to the following: (1) genetic and acquired host susceptibility, (2) metabolism and tissue levels of carcinogens, (3) levels of covalent adducts formed between carcinogens and DNA or other macromolecules, and (4) early cellular responses to carcinogen.
Overview
Substances, mixtures and exposure circumstances in this list have been classified by the IARC as Group 4: The agent (mixture) is probably not carcinogenic to humans. This category is used for agents or mixtures for which there is evidence suggesting lack of carcinogenicity in humans and in experimental animals. In some instances, agents or mixtures for which there is inadequate evidence of carcinogenicity in humans but evidence suggesting lack of carcinogenicity in experimental animals, consistently and strongly supported by a broad range of other relevant data, may be classified in this group.Further details can be found in the IARC Monographs.